Chiefs vs. Jaguars picks, odds, predictions for NFL Monday Night Football – CBS Sports

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The NFL Week 5 schedule will conclude with the Kansas City Chiefs visiting the Jacksonville Jaguars on ‘Monday Night Football.’ Kansas City (2-2) has rebounded from an 0-2 start with back-to-back wins over the Giants and Ravens. Jacksonville (3-1) has won three of its first four games for just the second time over the last 18 seasons. The Chiefs have won the last eight meetings between the teams, while the franchises have split eight all-time matchups in Jacksonville. Both teams have won and covered their last two games.
Kickoff is at 8:15 p.m. ET from EverBank Stadium in Jacksonville. Kansas City is a 3.5-point road favorite in the latest Jaguars vs. Chiefs odds, down one from the opening line, and the over/under for total points scored is 45.5, down two points from the opener. The Chiefs are -196 favorites on the money line (risk $196 to win $100), while the Jags are +163 underdogs (risk $100 to win $163). Before making any Chiefs vs. Jaguars picks, be sure to see what the SportsLine projection model has to say. 
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The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model is on a sizzling 39-20 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.  
Now, the model has zeroed in on Chiefs vs. Jaguars. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Jags vs. Chiefs:
Jaguars vs. Chiefs spread
Chiefs -3.5 at DraftKings Sportsbook
Jaguars vs. Chiefs over/under
45.5 points
Jaguars vs. Chiefs money line 
Chiefs -196, Jaguars +163
Jaguars vs. Chiefs picks
See picks at SportsLine
Jaguars vs. Chiefs streaming 
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As part of Kansas City winning eight straight versus the Jags, Patrick Mahomes is also 5-0 straight-up and 4-1 against the spread in his career versus Jacksonville. The Chiefs may be playing a different style of football than before, but what they are doing better than ever is protecting the ball. No team entered Week 5 with fewer turnovers than the one Kansas City has on the year, and the team is riding a 39-game win streak when winning the turnover battle, which is the third-longest streak by any team since 1960.
The Chiefs offense finally broke out last week as the 37 points they put on Baltimore were the most by the team in over two calendar years. In that contest, Mahomes became the fastest player to reach 250 career touchdown passes (116 games), and a good chunk of those have come on Monday nights. He owns a 27:8 TD:INT on Monday Night Football and has torched the Jaguars to historic proportions. Mahomes is the only quarterback since 1950 to be 5-0, or better, versus one team with a 70% completion rate and an average of at least 300 passing yards per game. See which team to back at SportsLine.
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After ranking dead last in takeaways last season, the Jaguars have done a complete reversal and now lead the NFL with 13 takeaways entering Week 5. Not only that, but they have the best turnover differential (+9) in the NFL, and no stat correlates more with winning and losing than turnover differential. Under first-year defensive coordinator, Anthony Campanile, Jacksonville has the No. 4 run defense, the No. 5 scoring defense and ranks sixth in redzone defense.
On offense, Trevor Lawrence has been sacked just three times, which is the fewest of any qualified quarterback. The former No. 1 overall pick has also risen to the challenge of being an underdog as he is 5-2-1 against the spread as an underdog over the last two seasons. He’s complemented in the backfield by Travis Etienne, whose 6.1 yards per carry lead the NFL as the Jags have the No. 4 rushing offense. Their commitment to the run and the ability to produce on the ground game could eat up the clock and keep Mahomes and company off the field. See which team to back at SportsLine. 
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For Jaguars vs. Chiefs on Monday Night Football, the model is leaning Under the total, projecting 45 combined points. It also says one side of the spread hits in well over 50% of simulations. See what it is at SportsLine.
Who wins Chiefs vs. Jags, and which side of the spread hits well over 50% of the time? Visit SportsLine now to see which side of the Jags vs. Chiefs spread you need to jump, all from the model that is 39-20 on top-rated picks since 2024, and find out.
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