Computer model locks in Jaguars vs. Broncos picks, score prediction – CBS Sports

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Two of the hottest teams in the league will meet in a high-stakes matchup in Week 16 of the 2025 NFL season as the Jacksonville Jaguars head west to face the Denver Broncos. The winner of this contest will keep a long winning streak going and more importantly, remain in position to be the No. 1 seed in the AFC. Both these teams lead their respective division heading into this game.
Kickoff from Empower Field at Mile High is set for 4:05 p.m. ET. The Broncos are 3-point favorites in the latest Jaguars vs. Broncos odds at DraftKings, and the total comes in at 47.5. Before you make any Broncos vs. Jaguars picks of your own, make sure to look at the top NFL picks from the SportsLine Projection Model, which simulates every NFL game 10,000 times.
When: Sunday, Dec. 21
Time: 4:05 p.m. ET
TV: FOX
Stream: Fubo  
Follow along: CBS Sports App
Odds: Broncos -3, over/under 47.5
Jacksonville has gotten a massive boost under first-year head coach Liam Coen, and Trevor Lawrence is heating up at the right time. The Jaguars are 9-5 ATS and have covered in five straight, while the Broncos are just 6-7-1 ATS despite being 12-2 overall. Denver is 6-8 to the Over while Jacksonville is 8-6 to the Over.
Bet it at DraftKings:
The SportsLine Projection Model sees the Broncos covering the three-point spread in 50% of simulations but likes Jacksonville on the money line. The Jaguars win in 41% of simulations to bring value as plus-money underdogs. The Under on the consensus line of 46.5 hits in 58% of simulations.
Jaguars vs. Broncos score prediction: Broncos 24, Jaguars 20

You’ve seen the model’s best bets for Jacksonville Jaguars vs. Denver Broncos. Now, get against the spread, total and money-line picks for every Week 16 NFL game here, all from the model that’s simulated every game 10,000 times. 
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